Abstract: Objective To verify the hemostatic effect of a new wound closure device on a porcine fatal traumatic hemorrhage model. Methods Ten male Bama miniature pigs with weight of 30 kg were randomly divided into group A and group B, with 5 pigs in each group. Group A was new wound closure device hemostasis group, while group B was standard gauze pressure bandaging hemostasis group. A swine model of fatal traumatic hemorrhage was established by inguinal femoral arteriovenous disconnection. Two kinds of hemostasis methods were used to stanch the bleeding of the swine traumatic hemorrhage model. The experimental observation time was 3 hours. The main indicators included bleeding volume, survival rate, survival time, and the secondary indicator included heart rate, blood pressure, arterial oxygen saturation. The experimental data obtained from the two methods were statistically analyzed. Results At the end of the experiment, all pigs in group A survived, and the survival time was＞ 180 minutes, while the average survival time of group B was 129 minutes. The amount of bleeding was (488.78±40.57) g in group A and (809.84±127.82) g in group B with significant difference (P=0.047). There was no significant difference in physiological parameters such as heart rate, blood pressure and oxygen saturation between the two groups. Conclusion Compared with the standard gauze dressing, the new wound closure device has advantages in controlling severe bleeding and reducing the amount of bleeding. The new wound closure device can effectively stop bleeding caused by femoral arteriovenous trauma in porcine, and the hemostatic effect is better than that of the standard gauze dressing.