Abstract: Objective To investigate the clinical effect of pranoprofen combined with sodium hyaluronate in treatment of xerophthalmia after diabetic cataract surgery. Methods One hundred and twenty patients with xerophthalmia after cataract surgery in Xuzhou Third People's Hospital from January 2016 to January 2018 were randomly divided into control group and experimental group (with 60 cases in each group). The control group was treated with sodium hyaluronate (1 drop, 4 times per day), and the experimental group was treated with pranoprofen (1 drop, 4 times per day) on the basis of sodium hyaluronate treatment. One month later, the clinical effect of the two groups was evaluated using tear fi lm rupture time (BUT), tear secretion test (SchrmerⅠ) and corneal fluorescent staining score. Results After treatment, BUT and SchrmerⅠ in the experimental group were significantly higher than those in the control group BUT, (11.07±1.66) s vs (7.50±1.02) s; SchrmerⅠ, (7.33±2.11) mm vs (5.03±0.82) mm, while the fluorescence staining score was significantly lower than that in the control group (2.13±0.68) vs (4.22±0.67) (all P＜ 0.05). Conclusion Compared with sodium hyaluronate alone, the clinical effect of praprofen combined with sodium hyaluronate in the treatment of xerophthalmia in senile diabetic patients after cataract surgery is more significant.