Abstract: As a critical part of the immune system, dendritic cell plays an important role in connecting innate immunity and acquired immunity. A large number of dendritic cells in various cell subsets are found in the lesions of patients with psoriasis. In recent years, it has been realized that dendritic cells can not only affect the initiation of disease by recognizing, uptaking and presenting antigens, but regulate the development of psoriasis by secreting relevant cytokines to promote T cell proliferation and differentiation to initiate downstream immune response or maintain inflammatory microenvironment in the intermediate or late stage of the disease. Due to the role of dendritic cells played in all stages of the disease, this research aims to summarize the role and mechanism of dendritic cells in the development of psoriasis.