非酒精性脂肪性肝病与常见内分泌代谢性疾病的关系及临床治疗综述

Relationship between non-alcoholic fatty liver disease and common endocrine and metabolic diseases

摘要: 近年来，非酒精性脂肪性肝病(non-alcoholic fatty liver disease，NAFLD)已成为我国第一大慢性肝病。与NAFLD相关的内分泌代谢性疾病的发病率也在逐年上升，其发病机制、病理生理学特征和临床后果较为复杂，被广泛研究。本文综述了NAFLD与临床上常合并的内分泌代谢性疾病的流行病学依据、病理生理学机制和治疗策略的研究现状，以期为NAFLD的临床管理提供更多方向。

Abstract: In recent years, non-alcoholic fatty liver disease (NAFLD) has been the largest chronic liver disease in China. The incidence of endocrine and metabolic diseases related to NAFLD is increasing year by year, exhibiting intricate pathogenesis, specific pathophysiological features and clinical consequences, which are widely studied. The review aims to discuss the relationship between NAFLD and endocrine and metabolic diseases which frequently occur in clinic from the aspect of epidemiological evidence, pathophysiological mechanism and therapeutic strategies, as well as to provide more directions for the clinical management of NAFLD.