曾琳, 高林, 陈凯琪, 魏强. 膀胱癌根治与盆腔淋巴结清扫数量研究进展[J]. 解放军医学院学报, 2021, 42(9): 974-977. DOI: 10.3969/j.issn.2095-5227.2021.09.016
引用本文: 曾琳, 高林, 陈凯琪, 魏强. 膀胱癌根治与盆腔淋巴结清扫数量研究进展[J]. 解放军医学院学报, 2021, 42(9): 974-977. DOI: 10.3969/j.issn.2095-5227.2021.09.016
ZENG Lin, GAO Lin, CHEN Kaiqi, WEI Qiang. Research advances in radical resection of bladder cancer and counts of dissected pelvic lymph node[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2021, 42(9): 974-977. DOI: 10.3969/j.issn.2095-5227.2021.09.016
Citation: ZENG Lin, GAO Lin, CHEN Kaiqi, WEI Qiang. Research advances in radical resection of bladder cancer and counts of dissected pelvic lymph node[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2021, 42(9): 974-977. DOI: 10.3969/j.issn.2095-5227.2021.09.016

膀胱癌根治与盆腔淋巴结清扫数量研究进展

Research advances in radical resection of bladder cancer and counts of dissected pelvic lymph node

  • 摘要: 膀胱癌是泌尿系统最常见的恶性肿瘤,主要发生于膀胱黏膜,也是全身十大常见肿瘤之一。根治性膀胱切除术联合盆腔淋巴结清扫是肌层浸润性膀胱癌的标准手术术式。但目前淋巴结清扫术的清扫范围尚存在争议。多项研究表明,相比标准淋巴结清扫,扩大淋巴结清扫可获得更多益处。但近年来也有研究发现,相比淋巴结的清扫范围,淋巴结的清扫数量对预后的影响更大。本综述对近年来淋巴结计数相关指标如淋巴结清扫数目、阳性淋巴结数以及淋巴结密度等对预后影响的相关研究进行总结,并对建立准确预测膀胱癌患者淋巴转移风险的模型进行了展望。

     

    Abstract: Bladder cancer is the most common malignant tumor of the urinary system, which mainly occurs in the bladder mucosa. While radical cystectomy (RC) combined with pelvic lymph node dissection (PLND) is the standard treatment for muscle-invasive bladder cancer (MIBC), the optimal range of PLND remains controversial. Several studies have shown that extended lymph node dissection (e-PLND) has more benefits than standard lymph node dissection (s-PLND). However, in recent years, some studies have found that the number of removed lymph nodes is a more important prognostic factor than the extent of lymphadenectomy. This article summarizes the research of the prognostic factors related to lymph node counts such as dissected lymph nodes, positive lymph nodes and lymph node density (LND) in recent years, and looks forward to establishing a model that can accurately predict the risk of lymphatic metastasis in patients with bladder cancer.

     

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