Abstract: Sepsis is easy to cause acute damage and dysfunction of the gastrointestinal tract, resulting in insufficient of nutrients in the patients, thereby affecting the nutritional status of patients, even threatening life. In clinical, nutritional support is an important treatment for patients with sepsis, which is divided into enteral nutritional support (EN) and parenteral nutritional support (PN). In recent years, the research conclusions on the effects of EN and PN on sepsis seem to be quite different from those in the past. The purpose of this article is to explore the role of EN and PN in sepsis from the recommendations of major guidelines, a large number of experimental foundations, clinical observations and so on, so as to provide references for clinicians in choosing suitable nutritional support and improving the prognosis of patients.