Abstract: In recent years, the role of Kisspeptin and its receptor KISS1R in reproductive field has attracted wide attention. Kisspeptin and KISS1R are not only expressed in the central nervous system to regulate endocrine function of female reproduction, but also highly expressed in the reproduction-related organs in female, such as ovary, uterus and placenta. These findings suggest that Kisspeptin not only plays a regulatory role in reproductive endocrine through the hypothalamic-pituitary-gonadal axis, but also locally regulates the functions of reproductive organs via direct interaction with KISS1R expressed in peripheral tissues. This paper reviews the distribution and local regulation of Kisspeptin/KISS1R in female reproductive relevant organs, so as to understand their modulatory roles in the reproductive endocrine functions.