Abstract: Circular RNA is a special kind of endogenous non-coding RNA, which is firstly found in plant viroid, yeast mitochondria and hepatitis D virus. In recent years, with the development of research, high-throughput sequencing results show that a large number of circRNAs are abnormally expressed in tissues or cell lines of pancreatic cancer. It also participates in the occurrence, development, drug resistance, autophagy and immune escape of pancreatic cancer by regulating downstream target molecules such as microRNA or RNA binding protein, which suggests that it has the potential to become a diagnostic marker and therapeutic target of pancreatic cancer. In this review, circRNAs that have been studied extensively in pancreatic cancer field in recent years are summarized and discussed in terms of its mechanism and application prospect.