Abstract:
Background Urine N-acetyl- β- Glucosaminase/creatinine (NAG/Crea) is a sensitive index of early renal injury, which has attracted much attention in recent years. However, there is no reference range for the elderly group.
Objective To explore the reference range of urine NAG and NAG/Crea in healthy elderly population.
Methods Urine samples from 915 cases of health examination in the Second Medical Center of Chinese PLA General Hospital from April to July in 2021 were collected. The samples were divided into young group and old group according to age (cut-off: 60 years). The urine samples of the two groups were tested for NAG and NAG/Crea, and the differences between the two groups were compared.
Results The urinary NAG and NAG/Crea in the young group were 9.93 (7.18, 13.7) U/L and 8.33 (6.49, 11.09) U/g·Cr, and they were 8.93 (6.58, 12.53) U/L and 10.19 (7.76, 14.05) U/g·Cr in the old group. The reference range of urine NAG did not need to distinguish gender and age (Z<Z*), which was 3.53 - 24.48 U/L. However, the formulation of urine NAG/Crea reference range needed to distinguish the age (Z>Z*), it was 4.24 - 21.93 U/g·Cr for under 60 years old group, and 4.61 - 27.83 U/g·Cr for the more than 60 years group.
Conclusion The reference range of urinary NAG and NAG/Crea in the elderly population is preliminarily established in this study, which provides a reference for clinicians to judge early renal injury.
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