Abstract: Objective To observe the effect of Parusweet^® on postprandial blood glucose and insulin levels in patients with type 2 diabetes mellitus（DM）. Methods Fifty-tree type 2 DM patients enrolled in this study were randomly divided into standard diet group and standard diet + Parusweet^® group according to their fasting blood glucose level.Their blood glucose and insulin levels and their AUC were measured 1 and 2 h after meal. Results The effective data were obtained from 40 type 2 DM patients（20 in standard diet group and 20 in standard diet+Parusweet^® group）.No significant difference was observed in blood glucose level and AUC 1 and 2h after meal between the two groups and in insulin levels 2h after meal between the two groups（P＞0.05）. Conclusion Parusweet^® does not increase postprandial blood glucose and insulin levels in type 2 DM patients,suggesting that it can be used as a sugar surrogate in such patients.