Abstract: Objective To assess the expressions of estrogen receptor（ER）,progestin receptor（PR）,and P53 in endometrial cancer and their effect on its prognosis. Methods Correlation of expressions of ER,PR and P53 in 173 endometrial cancer patients admitted to our hospital from January 2005 to March 2011 with the pathology and prognosis of endometrial cancer was analyzed. Results No significant difference was observed in expression of ER in different types and pathology of endometrial cancer.The survival rate of ER-positive patients was significantly higher than that of ER-negative patients（100% vs 88.3%,P＜0.05）.No significant difference was found in ER-positive patients with a survival rate ＞75% or ＜75%（100% vs 95.3%,P＞0.05）.The expression of PR was significantly different in different types and pathology of endometrial cancer.The survival rate of PR-positive and negative patients with a survival rate ＞75% or ＜75% was significantly different（P＜0.05）.The expression of P53 was significantly different in different types of endometrial cancer（P＜0.05） with no significant difference in pathology of endometrial carcinoma and in survival rate of P53-positive or negative patients.The survival rate of PR positive or negative patients with a survival rate ＞75% or ＜75% was significantly different（P＜0.05）. Conclusion ER,PR and P53 are correlated with the types of endometrial cancer and can thus be used as indications for its prognosis and for the judgment of whether it is malignant or benign.