Abstract: Objective To study the surgical procedure and therapeutic effect of non-cement total ankle replacement for osteoarthritis of ankle joint. Methods Eighteen patients（19 ankle-joints） with osteoarthritis of ankle joint underwent non-cement total ankle replacement and were followed up for 18.5 months（range 8-45 months）.Pain,motion and function of ankle joints were compared before and after operation.The function of ankle-joint was assessed with the Kofoed scoring system. Results The symptoms,signs and function of ankle-joint were improved in all patients after operation,with the extension,flexion and score of ankle-joint increased to 18.6°,28.3°,and 80.7 after operation from 8.8°,12.5°,and 42.2 before operation.No looseness and infection were found on X-ray film. Conclusion Non-cement total ankle replacement is an effective procedure for osteoarthritis of ankle joint.