Abstract: Objective To observe the analgesic effect of local anesthesia with compound lidocaine cream in patients undergoing blepharal plastic operation. Methods Sixty patients undergoing blepharal plastic operation were randomly divided into experimental group and control group.Patients both in control group and experimental group underwent operation under local anesthesia with compound lidocaine cream after routine skin disinfection.However,1h before operation for those in experimental group,a thin layer of compound lidocaine cream was evenly smeared on the surface of their eyes and covered with a transparent sealing dressing,which was washed before operation.Pain of patients was assessed according to the WHO numerical pain rating scale. Results The severity of pain was significantly lower in experimental group than in control group after local anesthesia with compound lidocaine cream. Conclusion Topical application of compound lidocaine cream before blepharal plastic operation can effectively alleviate the pain and discomfort of patients undergoing blepharal plastic operation.