Abstract: Large language models not only play a significant role in accelerating the dissemination of knowledge, optimizing clinical decision-making, and enhancing the patient experiences, but also provide a powerful impetus for the overall intelligent upgrade of the healthcare system. In this article, the typical applications of large language models in clinical medicine are reviewed, the existing problems and challenges of large language models are analyzed, and the developing trends of large language models in clinical medicine are prospected. By discussing the application and future prospects of large language models, we aim to inspire medical professionals and researchers to explore this field together, apply new artificial intelligence technologies represented by large language models to clinical practice, thereby improve the work efficiency and service quality of medical institutions.