Abstract: Objective To observe the pathogens,clinical features,diagnosis and treatment of chronic obstructive pulmonary disease（COPD） accompanying fungal infection. Methods Clinical data about 49 patients with COPD accompanying fungal infection admitted to our hospital,including their sputum identification and therapeutic effects,were retrospectively analyzed. Results Candida albicans,tropicalis,glabrata,parapsilosis,krusei,and Aspergillus were detected in the cultured sputum from 23,7,4,3,2,and 10 out of the 49 patients with COPD accompanying fungal infection.Complete recovery and effective outcome were achieved in 9（18.4%） and 27（55.1%）patients,respectively,after treatment with fluconazole and voriconazole. Conclusion Early diagnosis and treatment of COPD can improve its clinical curative effect and reduce its mortality.