影响肝内胆管癌切除术后患者生存率的多因素分析

Factors influencing survival of patients with intrahepatic cholangiocarcinoma after resection:A multiple factor analysis

摘要: 目的探讨影响肝内胆管癌术后患者生存的因素。方法对本院2000年1月-2010年12月收治的91例行肝脏切除术的肝内胆管癌患者进行随访和回顾性研究,分析影响肝内胆管癌患者术后生存的因素。结果多因素分析表明,术中失血量(＞400ml vs≤400ml:HR=2.973,P=0.04)和肿瘤分化程度(低分化vs中-高分化:HR=4.892,P=0.01)是患者术后生存的独立危险因素。结论影响肝内胆管癌切除术患者生存的独立危险因素为术中失血量和肿瘤分化程度,减少术中失血量或可改善患者的远期预后。

Abstract: Objective To study the factors influencing survival of patients with intrahepatic cholangiocarcinoma（ICC） after operation. Methods Factors influencing the survival of 91 ICC patients admitted to our hospital for operation from January 2000 to December 2010 were retrospectively analyzed. Results Multivariate analysis showed that intraoperative blood loss（＞400ml vs≤400ml,HR=2.973,P=0.04） and tumor differentiation（poor vs moderate-high differentiation,HR=4.892,P=0.01） were the two independent risk factors for the survival of ICC patients after operation. Conclusion Intraoperative blood loss and tumor differentiation are the independent prognostic factors for the survival of ICC patients after operation,thus reducing intraoperative blood loss can improve the long-term prognosis of such patients.