Abstract: The osteogenic differentiation is a complex dynamic balance involving the participations of human mesenchymal stem cells, adipose-derived stem cells, human periodontal ligament cells, pre-osteoblasts, osteoblasts and so on.As a kind of non-coding RNA with their transcripts of more than 200 bp in length, the long noncoding RNA (LncRNA) plays important roles as a regulatory molecule in a variety of mechanisms.Recent studies show that LncRNA also plays vital role in the osteogenic differentiation.In this review, we focus on the researches of regulation role of LncRNA on osteogenic differentiation in different cells and further introduce the progress in this area, expecting to provide basis for the following studies.